The Adelaide Institute for Sleep Health (AISH) was originally established in 1992 as the sleep disorders unit of the Repatriation General Hospital (RGH). In 2002 to support its mission and to establish a formal framework for its development fund and related business affairs, AISH was incorporated with the SA Office of Consumer Business Affairs as a not for profit organisation. AISH signed a Memorandum of Understanding with the RGH which was re-signed with the Southern Adelaide Local Health Network (SALHN) in 2010 and was effective to September 2015.

A Centre of Research Excellence in Sleep Disorders, known as AISH was established by Flinders University of South Australia in 2014 in recognition of the outstanding record of the AISH group research and postgraduate teaching over many years and the potential the Flinders University sees in AISH for further growth and research achievements.

Due to the termination of the Memorandum of Understanding in February 2015 the Clinical Service came under the direct administrative control of SALHN, as the Sleep Health Service within the Respiratory and Sleep Services Department, but the health practitioners working in the SALHN Sleep Health Service remain an integral part of the research and teaching endeavour and work in close cooperation with full time researchers at AISH, Flinders University.