The Adelaide Institute for Sleep Health (AISH) was originally established in 1992 as the sleep disorders unit of the Repatriation General Hospital (RGH). In 2002 to support its mission and to establish a formal framework for its development fund and related business affairs, AISH was incorporated with the SA Office of Consumer Business Affairs as a not for profit organisation. AISH signed a Memorandum of Understanding with the RGH which was re-signed with the Southern Adelaide Local Health Network (SALHN) in 2010 and was effective to September 2015.

AISH became a Centre of Research Excellence with Flinders University of South Australia in 2014 in recognition of its outstanding record of research and postgraduate teaching over many years and the potential the Flinders University sees in AISH for further growth and research achievement.